1.
Org Lett
; 19(16): 4339-4342, 2017 08 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28770608
RESUMO
A highly efficient preparation of enantiomerically pure syn aryl ß-hydroxy α-dibenzylamino esters is reported. The outcome was achieved via dynamic kinetic resolution and asymmetric transfer hydrogenation of aryl α-dibenzylamino ß-keto esters. The desired products were obtained in high yields (up to 98%) with excellent diastereoselectivity (>20:1 dr) and enantioselectivity (up to >99% ee). Furthermore, this method was applied for the gram-scale preparation of droxidopa.